I-Imperial College yaseLondon (ICL) iphambili kuphando lwezenzululwazi kwaye, ngeSebe le-Immunology and Inflammation kunye neSebe leNzululwazi yobuchopho, uphando lwayo lususela kwi-rheumatology kunye ne-hematology ukuya kwi-dementia, isifo sika-Parkinson kunye nomhlaza wobuchopho. Ukulawula uphando olulolo hlobo kufuna amaziko akumgangatho ophezulu, ngakumbi kugcino lweesampulu ezibalulekileyo zebhayoloji. UNeil Galloway Phillipps, uMphathi oMkhulu weLebhu kuwo omabini amasebe, uye waqaphela imfuneko yesisombululo esisebenzayo nesizinzileyo sogcino lwecryogenic.
Iimfuno ze-ICL
1.Umthamo ophezulu, inkqubo edityanisiweyo yokugcina ulwelo lwenitrogen
2.Ukunciphisa ukusetyenziswa kwenitrogen kunye neendleko zokusebenza
3.Ukuphuculwa kwesampulu yokhuseleko kunye nokuthotyelwa kwemithetho
4.Ufikelelo olukhuselekileyo nolusebenzayo lwabaphandi
5.Isisombululo esizinzileyo sokuxhasa amalinge ohlaza
Imingeni
I-ICL's Department of Immunology yayikade ixhomekeke kwi-13 eyahlukileyo engamanzi e-nitrogen (LN)2) iitanki zokugcina iisampuli zolingo lweklinikhi, iiseli zesathelayithi kunye neenkcubeko zeseli eziphambili. Le nkqubo yahlulahlulwe yatya ixesha ukuyigcina, ifuna ukubekwa esweni rhoqo kunye nokuzaliswa kwakhona.
UNeil uthi: “Ukuzalisa amatanki ali-13 kuthathe ixesha elininzi, kwaye ukugcina umkhondo wayo yonke into kuya kuba nzima ngakumbi. "Ibingumceli mngeni wezinto, kwaye besidinga indlela esebenzayo yokulawula ugcino lwethu."
Iindleko zokugcina iitanki ezininzi yayiyenye inkxalabo. LN2Ukusetyenziswa bekuphezulu, nto leyo ebinegalelo ekunyukeni kweendleko zokusebenza. Kwangaxeshanye, impembelelo yokusingqongileyo yokuhanjiswa rhoqo kwenitrogen yayingavisisani nokuzibophelela kwelebhu kuzinzo. “Besisebenzela ukufezekisa amabhaso awohlukeneyo, kwaye besisazi ukuba ukunciphisa ukusetyenziswa kwethu kwenitrogen kungenza umahluko omkhulu,” utshilo uNeil.
Ukhuseleko kunye nokuthotyelwa zizinto eziphambili eziphambili. Ngamatanki amaninzi asasazeka kwiindawo ezahlukeneyo, ukulandelela ukufikelela kunye nokugcina iirekhodi ezihlaziyiweyo kwakunzima. “Kubalulekile ukuba sazi ngqo ukuba ngubani ofikelela kwiisampulu, kwaye yonke into igcinwe ngokuchanekileyo ngokuhambelana nemigaqo yeHuman Tissue Authority (HTA),” wongeze watsho uNeil. “Inkqubo yethu endala ayizange ikwenze kube lula oko.”
Isisombululo
I-ICL yayisele inoluhlu lwezixhobo ezivela kwi-Haier Biomedical - eqala ukugcinwa okubandayo, iikhabhinethi zokhuseleko lwebhayoloji, i-CO2ii-incubators kunye ne-centrifuges - ukuphuhlisa ukuthembela kwizisombululo zenkampani.
UNeil kunye neqela lakhe ke basondela kwi-Haier Biomedical ukunceda ukujongana nale mingeni mitsha, ukufaka umthamo omkhulu we-CryoBio 43 LN.2i-biobank ukudibanisa zonke iitanki ezili-13 ezingatshintshiyo zibe yinkqubo eyodwa ephezulu. Utshintsho lwalungenamthungo, kunye neqela likaHaier elilawula ukufakwa kunye nokuqeqesha abasebenzi baselebhu. Inkqubo entsha yafakwa kwi-LN ekhoyo2indawo enohlengahlengiso olungephi. Ngenkqubo entsha ekhoyo, ukugcinwa kwesampulu kunye nokulawula kuye kwasebenza kakhulu. “Enye yeenzuzo ebezingalindelekanga kukuba singakanani na indawo esiyifumeneyo,” utshilo uNeil. “Ngawo onke loo matanki amadala asusiweyo, ngoku sinendawo eyongezelelekileyo kwilebhu yezinye izixhobo.”
Ukutshintshela kwindawo yogcino lwesigaba somphunga kuphucule ukhuseleko kunye nokulula kokusetyenziswa.“Ngaphambili, ngalo lonke ixesha sikhupha irack kwitanki yesigaba solwelo, ibiya kuthontsiza initrogen, nto leyo ibisoloko iyinkxalabo yokhuseleko.
UNeil kunye neqela lakhe bafumene inkqubo esebenzisekayo, kunye nenkqubo yoqeqesho kaHaier ebenza bakwazi ukukhawulezisa abasebenzisi bokugqibela.
Into engalindelekanga kodwa eyamkelekileyo yayingamanyathelo azenzekelayo anokurhoxiswa, enza ukufikelela kwitanki kube lula. "Ngamatanki angaphambili, abaphandi bebesoloko bephakamisa izinto xa bezolula. Nangona itanki entsha inde, amanyathelo asetyenziswa ngokucofa iqhosha, nto leyo eyenza ukuba ukudibanisa okanye ukususa iisampulu kube lula ukulawula," utshilo uNeil.
Ukugcina iisampulu ezixabisekileyo
Iisampulu ezigcinwe kwiziko le-ICL le-cryogenic zixabiseke kakhulu kuphando oluqhubekayo. “Ezinye zeesampulu esizigcinayo azinakutshintshwa kwaphela,” utshilo uNeil.
“Sithetha ngamalungiselelo eeseli ezimhlophe zegazi ezisuka kwizifo ezinqabileyo, iisampulu zolingo lwezonyango, kunye nezinye izinto ezibalulekileyo kuphando. Ezi sampuli azisetyenziswa nje elebhu; kwabelwana ngazo nabasebenzisana kwihlabathi liphela, nto leyo eyenza ukuba ingqibelelo yabo ibaluleke kakhulu. Ukusebenza kwezi seli yinto yonke. Uxolo lwengqondo singajonga iprofayile yobushushu nangaliphi na ixesha, kwaye ukuba sikhe saphicothwa, sinokubonisa ngokuzithemba ukuba yonke into igcinwe ngokuchanekileyo.
Ukuphucula ukuzinza kunye nokusebenza kakuhle kweendleko
Ukwaziswa kwe-biobank entsha kunciphise kakhulu ukusetyenziswa kwe-nitrogen engamanzi kwilebhu, ukuyisika ngokuphindwe kalishumi. “Itanki ngalinye kula madala ahlala malunga ne-125 yeelitha, ngoko ke ukuwadibanisa kwenze umahluko omkhulu,” ucacise watsho uNeil. “Ngoku sisebenzisa iqhezu lenitrogen ebesiyenza ngaphambili, kwaye lolona mpumelelo inkulu kwezemali nakwezokusingqongileyo.”
Ngokuhanjiswa kwenitrogen encinci efunekayo, ukukhutshwa kwekhabhoni kuncitshisiwe, ukuxhasa iinjongo zokuzinza kwelebhu. “Ayikho nje initrogen ngokwayo,” wongeze watsho uNeil. “Ukuba nokuhanjiswa okumbalwa kuthetha iilori ezimbalwa endleleni, kwaye amandla amancinci asetyenziswa ukuvelisa initrogen kwasekuqaleni.” Olu phuculo lubaluleke kakhulu kangangokuba i-Imperial ifumene iimbasa zozinzo kwi-LEAF kunye neMy Green Lab ngokuthathela ingqalelo iinzame zayo.
Ukuqukumbela
I-Haier Biomedical's cryogenic biobank iye yaguqula amandla okugcina i-ICL, iphucula ukusebenza kakuhle, ukhuseleko kunye nokuzinza ngelixa inciphisa kakhulu iindleko. Ngokuthotyelwa okungcono, ukhuseleko oluphuculweyo lwesampulu kunye nefuthe elincitshisiweyo lokusingqongileyo, uphuculo lube yimpumelelo engathethekiyo.
Iziphumo zeProjekthi
1.LN2ukusetyenziswa kuncitshiswe nge-90%, ukunciphisa iindleko kunye nokukhutshwa
2.Ukulandelela okusebenzayo ngakumbi kwesampulu kunye nokuthotyelwa kwe-HTA
3.Ugcino olukhuselekileyo lwesigaba somphunga kubaphandi
4.Ukunyuswa komthamo wokugcina kwinkqubo enye
5.Ukuqondwa ngamabhaso okuzinza
Ixesha lokuposa: Jun-23-2025